EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications
The EBF1-PDGFRB gene fusion accounts for< 1% of B-cell precursor acute lymphoblastic
leukemia (ALL) cases and occurs within the Philadelphia-like ALL subtype. We report 15 …
leukemia (ALL) cases and occurs within the Philadelphia-like ALL subtype. We report 15 …
MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy?
The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in
chromosomal translocations in a subtype of acute leukemia, which represents approximately …
chromosomal translocations in a subtype of acute leukemia, which represents approximately …
Treatment of childhood acute lymphoblastic leukemia: prognostic factors and clinical advances
LM Vrooman, LB Silverman - Current hematologic malignancy reports, 2016 - Springer
While the majority of children and adolescents with newly diagnosed childhood acute
lymphoblastic leukemia (ALL) will be cured, as many as 20% of patients will experience …
lymphoblastic leukemia (ALL) will be cured, as many as 20% of patients will experience …
IKZF1 status as a prognostic feature in BCR-ABL1–positive childhood ALL
A Van Der Veer, M Zaliova, F Mottadelli… - Blood, The Journal …, 2014 - ashpublications.org
Childhood BCR-ABL1–positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …
Defining low-risk high hyperdiploidy in patients with paediatric acute lymphoblastic leukaemia: a retrospective analysis of data from the UKALL97/99 and UKALL2003 …
Background High hyperdiploidy is the most common genetic subtype of childhood acute
lymphoblastic leukaemia and is associated with a good outcome. However, some patients …
lymphoblastic leukaemia and is associated with a good outcome. However, some patients …
[HTML][HTML] Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary …
NA Heerema, AJ Carroll, M Devidas… - Journal of clinical …, 2013 - ncbi.nlm.nih.gov
Purpose Five-year overall survival (OS) for children with B-cell precursor acute
lymphoblastic leukemia (B-ALL) exceeds 90% with risk-adapted therapy. Age, initial WBC …
lymphoblastic leukemia (B-ALL) exceeds 90% with risk-adapted therapy. Age, initial WBC …
[HTML][HTML] Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features
In childhood B-cell precursor acute lymphoblastic leukemia, cytogenetics is important in
diagnosis and as an indicator of response to therapy, thus playing a key role in risk …
diagnosis and as an indicator of response to therapy, thus playing a key role in risk …
Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia
Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical
utility at initial diagnosis. However, the genetic landscape and its clinical utility at relapse are …
utility at initial diagnosis. However, the genetic landscape and its clinical utility at relapse are …
Childhood B-acute lymphoblastic leukemia: a genetic update
JS Woo, MO Alberti, CA Tirado - Experimental hematology & oncology, 2014 - Springer
In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent
childhood hematological malignancy, as well as the leading cause of childhood cancer …
childhood hematological malignancy, as well as the leading cause of childhood cancer …
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …