Defining low-risk high hyperdiploidy in patients with paediatric acute lymphoblastic leukaemia: a retrospective analysis of data from the UKALL97/99 and UKALL2003 …
Background High hyperdiploidy is the most common genetic subtype of childhood acute
lymphoblastic leukaemia and is associated with a good outcome. However, some patients …
lymphoblastic leukaemia and is associated with a good outcome. However, some patients …
Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial
C Schwab, RE Cranston, SL Ryan, E Butler… - Leukemia, 2023 - nature.com
Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute
lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about …
lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about …
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 …
E Clappier, MF Auclerc, J Rapion, M Bakkus, A Caye… - Leukemia, 2014 - nature.com
Oncogenic subtypes in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
are used for risk stratification. However, a significant number of BCP-ALL patients are still …
are used for risk stratification. However, a significant number of BCP-ALL patients are still …
Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001
LM Vrooman, TM Blonquist, MH Harris… - Blood …, 2018 - ashpublications.org
Abstract Dana-Farber Cancer Institute (DFCI) ALL Consortium Protocol 05-001 tested a new
risk stratification system in children and adolescents with newly diagnosed acute …
risk stratification system in children and adolescents with newly diagnosed acute …
Recent advances in managing acute lymphoblastic leukemia
DJ DeAngelo, E Jabbour, A Advani - American Society of Clinical …, 2020 - ascopubs.org
Acute lymphoblastic leukemia (ALL) is characterized by chromosomal translocations and
somatic mutations that lead to leukemogenesis. The incorporation of pediatric-type regimens …
somatic mutations that lead to leukemogenesis. The incorporation of pediatric-type regimens …
Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and …
AV Moorman, H Robinson, C Schwab… - Journal of clinical …, 2013 - ascopubs.org
Purpose To evaluate the effect on outcome of intensifying therapy for patients with acute
lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 …
lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 …
Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
K Paulsson, E Forestier, H Lilljebjörn… - Proceedings of the …, 2010 - National Acad Sciences
High hyperdiploid acute lymphoblastic leukemia (ALL) is one of the most common
malignancies in children. It is characterized by gain of chromosomes, typically+ X,+ 4,+ 6,+ …
malignancies in children. It is characterized by gain of chromosomes, typically+ X,+ 4,+ 6,+ …
Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis
S Safavi, K Paulsson - Blood, The Journal of the American …, 2017 - ashpublications.org
Hypodiploidy< 40 chromosomes is an uncommon genetic feature of acute lymphoblastic
leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses …
leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses …
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
Predicting relapse risk in childhood acute lymphoblastic leukaemia
DT Teachey, SP Hunger - British journal of haematology, 2013 - Wiley Online Library
Intensive multi‐agent chemotherapy regimens and the introduction of risk‐stratified therapy
have substantially improved cure rates for children with acute lymphoblastic leukaemia …
have substantially improved cure rates for children with acute lymphoblastic leukaemia …