RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene
expression regulators in both normal development and disease. RBPs influence the fate of …

Simple Summary The treatment of pediatric acute lymphoblastic leukemia (ALL) has
improved dramatically over the past half-century thanks to the refinement of risk stratification …

Risk stratification is essential for the delivery of optimal treatment in childhood acute
lymphoblastic leukemia. However, current risk stratification algorithms dichotomize variables …

Introduction Over the years, the Hispanic population living in the United States has
consistently shown high incidence rates of childhood acute leukemias (AL). Similarly, high …

The genetics of acute lymphoblastic leukemia are becoming well understood and the
incidence of individual chromosomal abnormalities varies considerably with age …

Biomarkers are biological molecules found in body fluids or tissues, which can be
considered as indications of a normal or abnormal process, or of a condition or disease …

The potential prognostic value of conventional karyotyping in adult T-cell acute
lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified …

The strongest predictor of relapse in B-cell acute lymphoblastic leukemia (B-ALL) is the level
of persistence of tumor cells after initial therapy. The high mutation rate of the B-cell receptor …

Acute lymphoblastic leukemia (ALL) can be classified into different subgroups based on
recurrent genetic alterations. Here, targeted RNA sequencing was used to identify the novel …

Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically
heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML …