Harnessing human microbiomes for disease prediction

Y Liu, M Fachrul, M Inouye, G Méric - Trends in microbiology, 2024 - cell.com
The human microbiome has been increasingly recognized as having potential use for
disease prediction. Predicting the risk, progression, and severity of diseases holds promise …

[HTML][HTML] The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

N Li, L Wang, L Li, MZ Yang, QX Wang, XW Bai… - Military Medical …, 2023 - Springer
Regulation of gut microbiota and its impact on human health is the theme of intensive
research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating …

[HTML][HTML] Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants

H Dai, T Hou, Q Wang, Y Hou, Z Zhu, Y Zhu… - Cardiovascular …, 2023 - Springer
Background Gut microbiota imbalances have been suggested as a contributing factor to
atrial fibrillation (AF), but the causal relationship is not fully understood. Objectives To …

[HTML][HTML] Integration of polygenic and gut metagenomic risk prediction for common diseases

Y Liu, SC Ritchie, SM Teo, MO Ruuskanen, O Kambur… - Nature Aging, 2024 - nature.com
Multiomics has shown promise in noninvasive risk profiling and early detection of various
common diseases. In the present study, in a prospective population-based cohort with~ 18 …

[HTML][HTML] ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition

J Yan, W Duan, Q Gao, T Mao, M Wang, J Duan… - Pharmacological …, 2023 - Elsevier
In our previous multicenter study, we delineated the inherent metabolic features of colorectal
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …

[HTML][HTML] Gut microbiota, blood metabolites, and left ventricular diastolic dysfunction in US Hispanics/Latinos

K Luo, A Taryn, EH Moon, BA Peters, SD Solomon… - Microbiome, 2024 - Springer
Background Left ventricular diastolic dysfunction (LVDD) is an important precursor of heart
failure (HF), but little is known about its relationship with gut dysbiosis and microbial-related …

Mapping multi-omics characteristics related to short-term PM2. 5 trajectory and their impact on type 2 diabetes in middle-aged and elderly adults in Southern China

J Wang, W Hu, Z Xue, X Cai, S Zhang, F Li, L Lin… - Journal of Hazardous …, 2024 - Elsevier
The relationship between PM 2.5 and metabolic diseases, including type 2 diabetes (T2D),
has become increasingly prominent, but the molecular mechanism needs to be further …

[HTML][HTML] The relationship between atrial fibrillation and NLRP3 inflammasome: a gut microbiota perspective

Y Xing, L Yan, X Li, Z Xu, X Wu, H Gao, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) is a common clinical arrhythmia whose pathogenesis has not been fully
elucidated, and the inflammatory response plays an important role in the development of AF …

The dual role of 20 (S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis

Y Ruan, G Ren, M Wang, W Lv, K Shimizu, C Zhang - Phytomedicine, 2024 - Elsevier
Abstract Background Pulmonary Fibrosis (PF) is a progressive lung disease characterized
by the diffuse interstitial tissue, leading to severe breathing difficulties. The existing treatment …

The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review

V Abrignani, A Salvo, G Pacinella… - International Journal of …, 2024 - mdpi.com
The Mediterranean diet (MD), rich in minimally processed plant foods and in
monounsaturated fats but low in saturated fats, meat, and dairy products, represents one of …