Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Lipid peroxidation, including its prominent byproducts such as malondialdehyde (MDA) and
4-hydroxy-2-nonenal (4-HNE), has long been linked with worsened metabolic health in …

Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …

Moringa oleifera is one of the popular plants that have shown significant health benefits.
Certainly, preclinical evidence (predominantly from animal models) summarized in the …

The association of habitual coffee consumption with a lower risk of diseases, like type 2
diabetes mellitus, chronic liver disease, certain cancer types, or with reduced all-cause …

There is an increasing interest in the use of nutraceuticals and plant-derived bioactive
compounds from foods for their potential health benefits. For example, as a major active …