The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Tricyclic antidepressants, together with anticonvulsants, are considered to be first-line drugs
for the treatment of neuropathic pain. Antidepressants are analgesic in patients with chronic …

Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

Chronic pain syndromes encompass several clinical entities that frequently affect the
individuals' emotional and cognitive behaviours which, in turn, can also alter pain …

Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is
known about the mechanism underlying pain-comorbid NA, previous studies have …

Chronic pain causes both physical suffering and comorbid mental symptoms such as
anhedonia. However, the neural circuits and molecular mechanisms underlying these …

Summary Background Anderson–Fabry disease (AFD), an X‐linked lysosomal storage
disorder, leads to multi‐organ dysfunction and premature mortality. Depression in adults …

Pain and depression often co-occur, but the underlying mechanisms have not been
elucidated. Here, we used the spared nerve injury (SNI) model in mice to induce both …

Despite enormous progress in the field of pain management over the recent years, pain
continues to be a highly prevalent medical condition worldwide. In the developing countries …

The clinical burden faced by chronic pain patients is compounded by affective comorbidities,
such as depression and anxiety disorders. Emerging evidence suggests that reactive glial …