The baker's yeast Saccharomyces cerevisiae has become a powerful model in ecology and
evolutionary biology. A global effort on field survey and population genetics and genomics of …

Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous
loci to homozygous loci. This mutation event is widespread in organisms that have asexual …

Laboratory experimental evolution provides a window into the details of the evolutionary
process. To investigate the consequences of long-term adaptation, we evolved 205 …

Genome duplications are important evolutionary events that impact the rate and spectrum of
beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments …

Most humans are inhabited by the yeast Candida albicans at some point. While largely
harmless, it is the most common cause of yeast infections. Though previously unclear …

High-throughput sequencing has enabled genetic screens that can rapidly identify mutations
that occur during experimental evolution. The presence of a mutation in an evolved lineage …

Independently evolving populations may adapt to similar selection pressures via different
genetic changes. The interactions between such changes, such as in a hybrid individual …

The emergence of drug resistant microbes is an inevitable drawback of drug exposure and a
true illustration of Charles Darwin's evolution concept “natural selection”[1]. It is drug …

Background Aneuploidy can result in significant phenotypic changes, which can sometimes
be selectively advantageous. For example, aneuploidy confers resistance to antifungal …

Loss of heterozygosity (LOH) is observed during vegetative growth and reproduction of
diploid genotypes through mitotic crossovers, aneuploidy caused by nondisjunction, and …