Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …

Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

The manner in which white adipose tissue (WAT) expands and remodels directly impacts the
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes.
The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of
cardiovascular diseases (CVD) including coronary heart disease, heart failure …

Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …