The rate-limiting enzyme in serotonin synthesis is tryptophan hydroxylase (TPH). There are
two independent serotonin systems in the body characterized by two isoforms of TPH, TPH1 …

Objective To provide a comprehensive overview of the efficacy, safety, and tolerability of
antidepressants for pain according to condition. Design Overview of systematic reviews …

Background Older adults commonly experience depression and anxiety, yet are under-
represented in psychological treatment services. There is uncertainty about the outcomes …

Background Growing concerns about the impact of coronavirus disease 2019 (COVID-19)
will likely lead to increased mental health diagnoses and treatment. To provide a pre-COVID …

Objectives Offlabel prescriptions of antidepressants may be of special concern in older
adults. We aimed to study the potential offlabel use of antidepressants among adults≥ 65 …

The use of antidepressants is widespread in modern times. Thus, they present a potential
risk for ecosystems due to occurrence in domestic sewage containing unaltered metabolites …

The continual discharge of pharmaceuticals from wastewater treatment plants (WWTPs) into
the marine environment, even at concentrations as low as ng/L, can exceed levels that …

Objective To explore the efficacy and safety of semaglutide 2.4 mg in people with
overweight/obesity who were also being treated with antidepressants (ADs). Methods …

OBJECTIVES Antidepressants increase the risk of falls and fracture in older adults.
However, risk estimates vary considerably even in comparable populations, limiting the …

The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-
related drugs, and antidepressants) is common, with a prevalence estimates range of 19 …