Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

Background: Parasitic diseases including malaria, leishmaniasis and schistosomiasis take a
terrible toll of human life, health and productivity, especially in tropical and subtropical …

Herein, Trifluralin (TFL) laden transfersomes (TFS) were investigated against Cutaneous
Leishmaniasis (CL), via localized and targeted dermal delivery of TFL. Designed TFL-TFS …

Submicromolar concentrations of several dinitroaniline herbicides have been found to
specifically inhibit intracellular replication of the protozoan parasiteToxoplasma gondii …

Main-stay in treatment of leishmaniasis relies on chemotherapy but none of the current
drugs combines high activity and low toxicity at affordable costs. Dinitroanilines are a new …

Leishmania microtubules play an important role not only in cell division, but also in keeping
the shape of the parasite and motility of its free-living stages. Microtubules result from the …

The drugs presently in use against Chagas disease are very toxic, inducing a great number
of side effects. Alternative treatments are necessary, not only for Chagas disease but also for …

Novel dinitroaniline sulfonamides based on the herbicide oryzalin 3 were synthesized and
evaluated for activity against the parasitic protozoan Leishmania donovani and against …

Convenient and economical assays capable of screening many compounds are vital to
advance the development of drug therapy. This is particularly important for many of the …

Trifluralin, a dinitroaniline microtubule inhibitor currently in use as an herbicide, has been
shown to inhibit the proliferation of Plasmodium falciparum, Trypanosoma brucei, and …