Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

The classical theory of cortical systematic variation has been independently described in
reptiles, monotremes, marsupials and placental mammals, including primates, suggesting a …

Three-dimensional cell culture models have either relied on the self-organizing properties of
mammalian cells 1, 2, 3, 4, 5, 6 or used bioengineered constructs to arrange cells in an …

Cerebral organoids recapitulate human brain development at a considerable level of detail,
even in the absence of externally added signaling factors. The patterning events driving this …

SOX2 is a transcription factor conserved throughout vertebrate evolution, whose expression
marks the central nervous system from the earliest developmental stages. In humans, SOX2 …

Abstract Sixty years ago, Friedrich Sanides traced the origin of the tangential expansion of
the primate neocortex to two ancestral anlagen in the allocortex of reptiles and mammals …

Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor
1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan …

The human cerebral cortex is parcellated in hundreds of areas using neuroanatomy and
imaging methods. Alternatively, cortical areas can be classified into few cortical types …

The hippocampus, derived from medial regions of the telencephalon, constitutes a
remarkable brain structure. It is part of the limbic system, and it plays important roles in …

Brain development requires a precise balance between expansion of the neural progenitor
pool and the production of postmitotic neurons and glia. Disruption of this equilibrium results …