Tissue damage, irrespective from the underlying etiology, destroys tissue structure and,
eventually, function. In attempt to achieve a morpho-functional recover of the damaged …

Accumulating evidence indicates that the molecular pathways mediating wound healing
induce cell migration and localization of cytokines to sites of injury. Macrophages are …

As a key hub of malignant properties, the cancer microenvironment plays a crucial role
intimately connected to tumor properties. Accumulating evidence supports that the …

Glioblastoma (GBM) remains one of the most aggressive cancers, partially due to its ability
to migrate into the surrounding brain. The sphingolipid balance, or the balance between …

Allergy is defined as a complex chronic inflammatory condition in which genetic and
environmental factors are implicated. Sphingolipids are involved in multiple biological …

This study aimed to investigate the interactions between fingolimod, a sphingosine 1-
phosphate receptor (S1PR) agonist, and melanocortin receptors 1 and 5 (MCR1, MCR5). In …

Elucidating the mechanisms by which immune cells become dysfunctional in tumors is
critical to developing next-generation immunotherapies. We profiled proteomes of cancer …

Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents
and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the …

The long‐term inflammatory microenvironment is one of the main obstacles to inhibit acute
spinal cord injury (SCI) repair. The natural adipose tissue‐derived extracellular matrix …

As viruses are obligatory intracellular parasites, any step during their life cycle strictly
depends on successful interaction with their particular host cells. In particular, their …