Sphingolipids are key molecules in inflammation and defense against pathogens. Their role
in dectin-1/TLR2-mediated responses is, however, poorly understood. This study …

This paper presents the role of macrophage efferocytosis, the process of elimination of
apoptotic bodies—elements formed during vascular atherosclerosis. The mechanisms of …

Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These
play a diverse and intricate role in cellular processes like membrane trafficking, protein …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide
and Inflammation plays a critical role in the development of CVD. Despite considerable …

Intraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier
integrity in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice …

Multilineage-differentiating stress-enduring (Muse) cells are a type of pluripotent cell with
unique characteristics such as non-tumorigenic and pluripotent differentiation ability. After …

Background & Aims Studies have demonstrated that activated pancreatic stellate cells
(PSCs) play a crucial role in pancreatic fibrogenesis in chronic pancreatitis (CP); however …

The lipidome of immune cells during infection has remained unexplored, although evidence
of the importance of lipids in the context of immunity is mounting. In this study, we performed …

The relationship between sphingolipid levels and NAFLD pathology has been recognized
for some time. Numerous studies using pharmacological and genetic approaches in vitro …

Background Fingolimod (FTY720), a novel immunomodulator, was found to suppress the
severity of collagen-induced arthritis (CIA) in mice. However, the potential molecular …