Expression of sphingosine‑1‑phosphate receptor 2 is correlated with migration and invasion of human colon cancer cells: A preliminary clinical study

J Yan, Y Chen, Q Wu, L Shao… - Oncology …, 2022 - spandidos-publications.com
Abstract Sphingosine‑1‑phosphate (S1P) is a bioactive phospholipid that serves as a potent
mediator of cell proliferation, differentiation and apoptosis by binding to S1P receptors …

Host M-CSF induced gene expression drives changes in susceptible and resistant mice-derived BMdMs upon Leishmania major infection

C Bouabid, S Rabhi, K Thedinga, G Barel… - Frontiers in …, 2023 - frontiersin.org
Leishmaniases are a group of diseases with different clinical manifestations. Macrophage-
Leishmania interactions are central to the course of the infection. The outcome of the …

The Oncogenic lipid sphingosine-1-phosphate impedes the phagocytosis of tumor cells by M1 macrophages in diffuse large B cell lymphoma

TA Perry, N Masand, K Vrzalikova, M Pugh, W Wei… - Cancers, 2024 - mdpi.com
Simple Summary Diffuse large B cell lymphoma (DLBCL), the most common form of non-
Hodgkin lymphoma, is clinically aggressive and associated with poor patient outcomes …

Analysis of the Sphingolipidome in NAFLD

D Montefusco, J Lambert, A Anderson… - … : Methods and Protocols, 2022 - Springer
The relationship between sphingolipid levels and NAFLD pathology has been recognized
for some time. Numerous studies using pharmacological and genetic approaches in vitro …

A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic …

Y Qu, Y Wang, T Wu, X Liu, H Wang, D Ma - Lipids in Health and Disease, 2023 - Springer
Cardiac cachexia is a deadly consequence of advanced heart failure that is characterised by
the dysregulation of adipose tissue homeostasis. Once cachexia occurs with heart failure, it …

Síndrome metabólico como determinante en la complicación de pacientes COVID-19

K Minchola, R Mozo, J Moncada… - Revista Médica de …, 2021 - revistas.unitru.edu.pe
La obesidad, diabetes, hipertensión y dislipidemia han sido asociados con mayor severidad
y mortalidad de COVID-19; esto establece una posible relación entre el síndrome …

Molecular mechanisms of calcium signaling during phagocytosis

P Nunes-Hasler, M Kaba, N Demaurex - Molecular and Cellular Biology of …, 2020 - Springer
Abstract Calcium (Ca 2+) is a ubiquitous second messenger involved in the regulation of
numerous cellular functions including vesicular trafficking, cytoskeletal rearrangements and …

Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization

H Qiu, J Liu, J You, O Zhou, C Hao, Y Shu, D Ma… - Genes & …, 2024 - Elsevier
Pulmonary fibrosis is a devastating lung disease without effective treatment options.
Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling molecule …

Genetic Tools for Studying the Roles of Sphingolipids in Viral Infections

G Guzman, C Creek, S Farley, FG Tafesse - Virus-Host Interactions …, 2022 - Springer
Sphingolipids are a critical family of membrane lipids with diverse functions in eukaryotic
cells, and a growing body of literature supports that these lipids play essential roles during …

Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal–Induced Interleukin-1β Production

M Qadri, S ElSayed, KA Elsaid - Journal of Pharmacology and Experimental …, 2021 - ASPET
Gout is a chronic inflammatory arthritis caused by monosodium urate monohydrate (MSU)
crystal deposits in joints of lower limbs. Phagocytic uptake of MSU crystals by joint-resident …