Background Activation of the farnesoid X receptor (FXR) reduces renal inflammation, but the
underlying mechanisms remain elusive. Neutrophil extracellular traps (NETs) are webs of …

Background: Gut microbiota contributes to the regulation of host immune response and
homeostasis. Bile acid (BA) derivatives from gut microbiota can affect the differentiation and …

Metastasis is the leading cause of cancer-related deaths and innate immune cells are critical
players in the metastatic microenvironment. Here, we explore the implications of harnessing …

Im zweiten Teil dieser Arbeit wurden in Blutproben von Patienten mit einer Stenose der A.
carotis oder einer pAVK die Konzentration von S1P und den Zytokinen (IL1B, IL10 und …

We appreciate the positive comment, from Drs. Menno Hoekstra Ezra J. van der Wel, and
Miranda Van Eck, on our recent work of PLTP deficiency-mediated atherosclerosis …

Axial spondyloarthritis (axSpA) is a progressive arthritic condition that is characterized by
TNF and IL-17-mediated enthesitis. Clinical and observational evidence suggests a linkage …

Bone is a constantly active organ, undergoing osteoclast-led bone resorption and osteoblast-
induced bone formation. In homeostatic conditions, levels of resorption and formation are …

The sphingolipid sphingosine-1-phosphate (S1P) promotes tumor development through a
variety of mechanisms including promoting proliferation, survival, and migration of cancer …

Abstract Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a major limiting side effect
of many common chemotherapeutics often leading patients to terminate their chemotherapy …

As viruses are obligatory intracellular parasites, any step during their life cycle strictly
depends on successful interaction with their particular host cells. In particular, their …