Studies investigating the proteome of skeletal muscle present clear evidence that protein
metabolism is altered in muscle of humans with obesity. Moreover, muscle quality (ie …

Obese individuals have reduced quadriceps muscle strength relative to body mass that may
increase the rate of progression of knee osteoarthritis (OA). The purpose of this study was to …

BACKGROUND & AIMS: Age-related inflammation and insulin resistance (IR) have been
implicated in the inability of old muscles to properly respond to anabolic stimuli such as …

Plasma fatty acids (FAs) and oxidant status contribute to the etiology of sarcopenia in the
elderly concurring to age-related muscle loss and elderly frailty through several mechanisms …

A central characteristic of insulin resistance is the impaired ability for insulin to stimulate
glucose uptake into skeletal muscle. While insulin resistance can occur distal to the …

The aim of this study was to determine the effect of 14 days of 5-aminoimidazole-4-
carboxamide-1β-4-ribofuranoside (AICAR) treatment on mammalian target of rapamycin …

Previously, we showed that offspring from obese rat dams were hyperphagic, with increased
adiposity, hyperlipidaemia and glucose intolerance associated with increased orexigenic …

Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity
are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of …

Chronic obesity and insulin resistance are considered to inhibit contraction-induced muscle
hypertrophy, through impairment of mammalian target of rapamycin complex 1 (mTORC1) …

The aim of this study was to evaluate the effect of overload‐induced hypertrophy on extensor
digitorum longus (EDL) and soleus muscles of streptozotocin‐induced diabetic rats. The …