Quality assurance procedures for mass spectrometry untargeted metabolomics. a review
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …
capabilities for the investigation of health and disease, as well as the wide applicability for …
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy
WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …
Global metabolic profiling procedures for urine using UPLC–MS
The production of'global'metabolite profiles involves measuring low molecular-weight
metabolites (< 1 kDa) in complex biofluids/tissues to study perturbations in response to …
metabolites (< 1 kDa) in complex biofluids/tissues to study perturbations in response to …
Method validation strategies involved in non-targeted metabolomics
Non-targeted metabolomics is the hypothesis generating, global unbiased analysis of all the
small-molecule metabolites present within a biological system, under a given set of …
small-molecule metabolites present within a biological system, under a given set of …
Development of a robust and repeatable UPLC− MS method for the long-term metabolomic study of human serum
E Zelena, WB Dunn, D Broadhurst… - Analytical …, 2009 - ACS Publications
A method for performing untargeted metabolomic analysis of human serum has been
developed based on protein precipitation followed by Ultra Performance Liquid …
developed based on protein precipitation followed by Ultra Performance Liquid …
Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry
SJ Bruce, I Tavazzi, V Parisod, S Rezzi… - Analytical …, 2009 - ACS Publications
The following study investigates the preparation of human blood plasma for metabolomic
profiling analysis by ultrahigh performance liquid chromatography coupled to time-of-flight …
profiling analysis by ultrahigh performance liquid chromatography coupled to time-of-flight …
Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review
The metabolome is the set of small molecular mass organic compounds found in a given
biological media. It includes all organic substances naturally occurring from the metabolism …
biological media. It includes all organic substances naturally occurring from the metabolism …
Controlling the quality of metabolomics data: new strategies to get the best out of the QC sample
The type and use of quality control (QC) samples is a 'hot topic'in metabolomics. QCs are not
novel in analytical chemistry; however since the evolution of using QCs to control the quality …
novel in analytical chemistry; however since the evolution of using QCs to control the quality …
High resolution mass spectrometry based techniques at the crossroads of metabolic pathways
C Junot, F Fenaille, B Colsch… - Mass spectrometry …, 2014 - Wiley Online Library
The metabolome is the set of small molecular mass compounds found in biological media,
and metabolomics, which refers to as the analysis of metabolome in a given biological …
and metabolomics, which refers to as the analysis of metabolome in a given biological …
Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic …
In this study, we assessed three liquid chromatographic platforms: reversed phase (RP),
aqueous normal phase (ANP), and hydrophilic interaction (HILIC) for the analysis of polar …
aqueous normal phase (ANP), and hydrophilic interaction (HILIC) for the analysis of polar …