Background Few attempts have been made to estimate the public return on investment in
medical research. The total costs and benefits to society of a clinical trial, the final step in …

Pagulayan KF, Temkin NR, Machamer J, Dikmen SS. A longitudinal study of health-related
quality of life after traumatic brain injury. OBJECTIVE: To examine the longitudinal course of …

Prophylactic antiepileptic treatment in patients with non-traumatic, non-aneurysmatic
spontaneous intracerebral hemorrhage (SICH) is controversial. The purpose of our study …

Over decades, the prevailing standard in drug discovery was the concept of designing highly
selective compounds that act on individual drug targets. However, more recently, multi-target …

Antiepileptic drugs as prophylaxis for postcraniotomy seizures - Greenhalgh, J - 2020 |
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Abstract Background About 2.8 million TBI-related emergency department visits,
hospitalizations and deaths occurred in 2013 in the United States. Post-traumatic epilepsy …

We examined, among those persons working preinjury, the risk of unemployment 1 year
after traumatic brain injury (TBI) relative to expected risk of unemployment for the sample …

Background There is controversy regarding the precise mechanism by which epilepsy
results after traumatic brain injury (TBI). Previous reports have suggested that mesial …

Sleep and wake are defined through physiological and behavioral criteria and can be
typically separated into non‐rapid eye movement (NREM) sleep stages N1, N2, and N3 …

With the growth in antiepileptic drug treatment, the question arises as to what extent we are
merely treating the symptom (ie the seizures) rather than the underlying disease process (ie …