Rationale Nicotine affects many aspects of human cognition, including attention and
memory. Activation of nicotinic acetylcholine receptors (nAChRs) in neuronal networks …

Tobacco use is a major health problem that is estimated to cause 4 million deaths a year
worldwide. Nicotine is the main addictive component of tobacco. It acts as an agonist to …

Nicotinic acetylcholine receptors (nAChRs) are expressed in the hippocampus, and their
functional roles are beginning to be delineated. The effect of nAChR activation on the activity …

Evidence gathered from epidemiologic and behavioral studies have indicated that neuronal
nicotinic receptors (nAChRs) are intimately involved in the pathogenesis of a number of …

Acetylcholine is a major neurotransmitter that modulates cortical functions. In addition to
basal forebrain neurons that give rise to the principal cholinergic input into the cortex, a …

Basal forebrain neurons play important parts in processes of cortical activation and memory
that have been attributed to the cortically projecting, cholinergic neurons. Yet, non …

Anxiety disorders are a group of crippling mental diseases affecting millions of Americans
with a 30% lifetime prevalence and costs associated with healthcare of $42.3 billion. While …

This article provides a review of the effects of activation of muscarinic and nicotinic receptors
on the physiological properties of circuits in the hippocampal formation. Previous articles …

Acetylcholine has been implicated in both the pathophysiology and treatment of a number of
psychiatric disorders, with most of the data related to its role and therapeutic potential …

In this paper, we report on the pharmacological and functional profile of SSR180711 (1, 4-
Diazabicyclo [3.2. 2] nonane-4-carboxylic acid, 4-bromophenyl ester), a new selective α7 …