Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …
worldwide. With no Food and Drug Administration approved drugs, current treatment options …
Current status and future trends of the global burden of MASLD
L Miao, G Targher, CD Byrne, YY Cao… - Trends in Endocrinology & …, 2024 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
common chronic liver disease globally, affecting more than a third of the world's adult …
common chronic liver disease globally, affecting more than a third of the world's adult …
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
D Hendriks, JF Brouwers, K Hamer, MH Geurts… - Nature …, 2023 - nature.com
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the
paucity of human-relevant models for target discovery and compound screening. Here we …
paucity of human-relevant models for target discovery and compound screening. Here we …
Emerging role of aging in the progression of NAFLD to HCC
Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …
Insights into nonalcoholic fatty-liver disease heterogeneity
M Arrese, JP Arab, F Barrera… - Seminars in liver …, 2021 - thieme-connect.com
The acronym nonalcoholic fatty-liver disease (NAFLD) groups a heterogeneous patient
population. Although in many patients the primary driver is metabolic dysfunction, a complex …
population. Although in many patients the primary driver is metabolic dysfunction, a complex …
Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)
CM Flessa, I Kyrou, N Nasiri‐Ansari… - Journal of Cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …
Nonalcoholic steatohepatitis drug development pipeline: an update
NWS Chew, CH Ng, E Truong… - Seminars in Liver …, 2022 - thieme-connect.com
Nonalcoholic steatohepatitis (NASH) is a burgeoning global health crisis that mirrors the
obesity pandemic. This global health crisis has stimulated active research to develop novel …
obesity pandemic. This global health crisis has stimulated active research to develop novel …
[HTML][HTML] Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction
Primary nonalcoholic fatty liver disease (NAFLD) is bi-directionally associated with the
metabolic syndrome and its constitutive features (“factors”: impaired glucose disposal …
metabolic syndrome and its constitutive features (“factors”: impaired glucose disposal …
Nonalcoholic fatty liver disease and endocrine axes—a scoping review
M Von-Hafe, M Borges-Canha, C Vale, AR Leite… - Metabolites, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease.
NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine …
NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine …
Design of hepatic targeted drug delivery systems for natural products: insights into nomenclature revision of nonalcoholic fatty liver disease
R Tang, R Li, H Li, XL Ma, P Du, XY Yu, L Ren… - Acs Nano, 2021 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-dysfunction-
associated fatty liver disease (MAFLD), affects a quarter of the worldwide population. Natural …
associated fatty liver disease (MAFLD), affects a quarter of the worldwide population. Natural …