Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

Current status and future trends of the global burden of MASLD

L Miao, G Targher, CD Byrne, YY Cao… - Trends in Endocrinology & …, 2024 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
common chronic liver disease globally, affecting more than a third of the world's adult …

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

D Hendriks, JF Brouwers, K Hamer, MH Geurts… - Nature …, 2023 - nature.com
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the
paucity of human-relevant models for target discovery and compound screening. Here we …

Emerging role of aging in the progression of NAFLD to HCC

Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

Insights into nonalcoholic fatty-liver disease heterogeneity

M Arrese, JP Arab, F Barrera… - Seminars in liver …, 2021 - thieme-connect.com
The acronym nonalcoholic fatty-liver disease (NAFLD) groups a heterogeneous patient
population. Although in many patients the primary driver is metabolic dysfunction, a complex …

Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)

CM Flessa, I Kyrou, N Nasiri‐Ansari… - Journal of Cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …

Nonalcoholic steatohepatitis drug development pipeline: an update

NWS Chew, CH Ng, E Truong… - Seminars in Liver …, 2022 - thieme-connect.com
Nonalcoholic steatohepatitis (NASH) is a burgeoning global health crisis that mirrors the
obesity pandemic. This global health crisis has stimulated active research to develop novel …

[HTML][HTML] Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction

A Lonardo, AK Singal, N Osna… - Metabolism and target …, 2022 - ncbi.nlm.nih.gov
Primary nonalcoholic fatty liver disease (NAFLD) is bi-directionally associated with the
metabolic syndrome and its constitutive features (“factors”: impaired glucose disposal …

Nonalcoholic fatty liver disease and endocrine axes—a scoping review

M Von-Hafe, M Borges-Canha, C Vale, AR Leite… - Metabolites, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease.
NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine …

Design of hepatic targeted drug delivery systems for natural products: insights into nomenclature revision of nonalcoholic fatty liver disease

R Tang, R Li, H Li, XL Ma, P Du, XY Yu, L Ren… - Acs Nano, 2021 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-dysfunction-
associated fatty liver disease (MAFLD), affects a quarter of the worldwide population. Natural …