Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

SA Hosseini, F Zahedipour, T Sathyapalan… - …, 2021 - Wiley Online Library
Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of
the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several …

Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases

Y Tu, Y Yang, Y Li, C He - Pharmacological research, 2021 - Elsevier
Naturally occurring coumestans are known as a collection of plant-derived polycyclic
aromatic secondary metabolites which are characterized by the presence of an oxygen …

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

R Fan, J Sui, X Dong, B Jing, Z Gao - Free Radical Biology and Medicine, 2021 - Elsevier
Acute pancreatitis (AP) is an inflammatory disorder associated with multiple organ failure.
Pyroptosis and ferroptosis are two newly recognized cell death, and whether pyroptosis and …

Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-β mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo …

SB Andugulapati, K Gourishetti, SK Tirunavalli… - Phytomedicine, 2020 - Elsevier
Abstract Background: Idiopathic Pulmonary Fibrosis (IPF) is a progressive inflammatory
disorder driven by a fibrotic cascade of events such as epithelial to mesenchymal transition …

Macrophage inactivation by small molecule wedelolactone via targeting sEH for the treatment of LPS-induced acute lung injury

J Zhang, M Zhang, XK Huo, J Ning, ZL Yu… - ACS central …, 2023 - ACS Publications
Soluble epoxide hydrolase (sEH) plays a critical role in inflammation by modulating levels of
epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs). Here, we investigate …

Therapeutic potential of traditional Chinese medicine for interstitial lung disease

YM Zhou, XR Dong, D Xu, J Tang, YL Cui - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Interstitial lung disease (ILD) is a chronic lung dysfunction
disease with a poor prognosis and poor recovery. The clinically used therapeutic drugs …

Wedelolactone: a molecule of interests

NM Ha, NQ Hop, NT Son - Fitoterapia, 2023 - Elsevier
Background The search for bioactive molecules from medicinal plants of the family
Asteraceae has been one of the targets in various phytochemical and pharmacological …

Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and p38 MAPK-mediated NF-κB signaling pathways

Y Xiong, X Cui, Y Zhou, G Chai, X Jiang, G Ge… - International …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible inflammatory disease with a
high mortality rate and limited therapeutic options. This study explored the potential role and …

The role of natural products in the prevention and treatment of pulmonary fibrosis: A review

L Wang, S Li, Y Yao, W Yin, T Ye - Food & function, 2021 - pubs.rsc.org
Pulmonary fibrosis is an incurable end-stage lung disease and remains a global public
health problem. Although there have been some breakthroughs in understanding the …

[HTML][HTML] Fisetin alleviated bleomycin-induced pulmonary fibrosis partly by rescuing alveolar epithelial cells from senescence

L Zhang, X Tong, J Huang, M Wu, S Zhang… - Frontiers in …, 2020 - frontiersin.org
Idiopathic pulmonary fibrosis is an aging-associated disease, satisfactory therapies are not
yet available. Accelerated senescence of alveolar epithelial cells plays an important part in …