SEdb 2.0: a comprehensive super-enhancer database of human and mouse
Y Wang, C Song, J Zhao, Y Zhang, X Zhao… - Nucleic Acids …, 2023 - academic.oup.com
Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …
[HTML][HTML] Pharmacological therapy of metabolic dysfunction-associated steatotic liver disease-driven hepatocellular carcinoma
Y Wang, JS Fleishman, T Li, Y Li, Z Ren… - Frontiers in …, 2024 - frontiersin.org
In light of a global rise in the number of patients with type 2 diabetes mellitus (T2DM) and
obesity, non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction …
obesity, non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction …
[HTML][HTML] Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile
C Bailly - Plants, 2023 - mdpi.com
The genus Ruta in the family Rutaceae includes about 40 species, such as the well-known
plants R. graveolens L.(common rue) or R. chalepensis L.(fringed rue), but also much lesser …
plants R. graveolens L.(common rue) or R. chalepensis L.(fringed rue), but also much lesser …
Scoparone induces both apoptosis and ferroptosis via multiple mechanisms in non-small-cell lung cancer cells
H Shen, Y Wei, Q Yang, Y Cai, K Zhu, X Chen - Toxicology in Vitro, 2023 - Elsevier
The present study investigated the anti-tumour effects of scoparone, also known as 6, 7-
dimethoxycoumarin, in non-small-cell-lung cancer (NSCLC) cells. It was discovered that …
dimethoxycoumarin, in non-small-cell-lung cancer (NSCLC) cells. It was discovered that …
Scoparone attenuates glioma progression and improves the toxicity of temozolomide by suppressing RhoA/ROCK1 signaling
Y Zhou, Z Han, Z Zhao, J Zhang - Environmental Toxicology, 2024 - Wiley Online Library
Background Glioma, a type of malignant brain tumor, has become a challenging health
issue globally in recent years. Methods In this study, we investigated the potential …
issue globally in recent years. Methods In this study, we investigated the potential …
[HTML][HTML] Scoparone inhibits breast cancer cell viability through the NF‑κB signaling pathway
X Wu, X Li, J Li, X Zhao, Y Cui… - Experimental and …, 2023 - spandidos-publications.com
Scoparone (SCO) is a compound found in the stems and leaves of Artemisia capillaris. The
pharmacological uses of SCO include significant hypotensive, cholagogic, anti …
pharmacological uses of SCO include significant hypotensive, cholagogic, anti …
Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer
S Huang, L Lin, Y Ma, Q Zhu, N Weng - European Journal of Pharmacology, 2023 - Elsevier
Colorectal cancer (CRC) is one of most common malignancies worldwide, yet curative
therapy remains a clinical challenge. Here, we demonstrate that scoparone (Scop), a …
therapy remains a clinical challenge. Here, we demonstrate that scoparone (Scop), a …
Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation
SW Kim, CW Kim, HS Kim - Animal Cells and Systems, 2024 - Taylor & Francis
Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of
cancer-related deaths in women worldwide. Monoclonal antibodies that block programed …
cancer-related deaths in women worldwide. Monoclonal antibodies that block programed …
[HTML][HTML] Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells
J Xu, D Xue, Y Li, J Zhou, H Chen, L Fan - Heliyon, 2024 - cell.com
Abstract Background Anaplastic Thyroid Carcinoma (ATC) is a rare and deadly malignant
tumor in humans. It is prone to developing resistance to radiotherapy and chemotherapy …
tumor in humans. It is prone to developing resistance to radiotherapy and chemotherapy …
Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches
M Gu, Y Liu, P Xin, W Guo, Z Zhao, X Yang, R Ma… - Cancer Letters, 2024 - Elsevier
The gastrointestinal tract can be affected by a number of diseases that pancreatic cancer
(PC) is a malignant manifestation of them. The prognosis of PC patients is unfavorable and …
(PC) is a malignant manifestation of them. The prognosis of PC patients is unfavorable and …