Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system,
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …

Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction
between host‐specific genetic background and multiple risk factors. Globally, CCA …

Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features
of cholangiocyte differentiation: cholangiocarcinomas are categorized according to …

PURPOSE No standard adjuvant treatment currently is recommended in localized biliary
tract cancer (BTC) after surgical resection. We aimed to assess whether gemcitabine and …

Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal hepatobiliary neoplasm whose
incidence is increasing. Largely neglected for decades as a rare malignancy and frequently …

Abstract N6-methyladenosine (m6A) has been reported as an important mechanism of
posttranscriptional regulation. Programmed death-ligand 1 (PD-L1) is a primary immune …

Background Next-generation sequencing has identified actionable genetic aberrations in
intrahepatic cholangiocarcinomas (iCCA), including the fibroblast growth factor receptor 2 …

Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal
disorders; however, its effect on antitumor immunity in the liver is largely unknown. Here we …

Purpose: Various genetic driver aberrations have been identified among distinct anatomic
and clinical subtypes of intrahepatic and extrahepatic cholangiocarcinoma, and these …

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of …