Unveiling the potential of isatin-grafted phenyl-1, 2, 3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments
The use of VEGFR-2 inhibitors as a stand-alone treatment has proven to be ineffective in
clinical trials due to the robustness of cellular response loops that lead to treatment …
clinical trials due to the robustness of cellular response loops that lead to treatment …
Discovery of new 1, 3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in …
Interest has been generated in VEGFR-2 and c-MET as potential receptors for the treatment
of different malignancies. Using aryl pyridine derivatives with 1, 3-diphenylurea attached, a …
of different malignancies. Using aryl pyridine derivatives with 1, 3-diphenylurea attached, a …