Background: Nanomedicine is an emerging therapeutic modality. Nanoparticles (NPs) are
potential vehicles for delivery of anticancer therapeutics. NPs can be designed to facilitate …

The abnormal structure and function of blood vessels in the TME are obvious characteristics
of the tumour. Abnormal blood vessels with high leakage support the occurrence of …

Due to the high morbidity and mortality of cancer, it has become an urgent matter to develop
an effective and a safe treatment strategy. Nanoparticles (NP) based drug delivery systems …

Brain tumor is one of the most challenging diseases to treat. The major obstacle in the
specific drug delivery to brain is blood–brain barrier (BBB). Mostly available anti-cancer …

In order to enhance the penetration of small interference RNA against the polo-like kinase I
(siPLK1) across BBB to treat glioblastoma (GBM), transferrin (Tf) modified magnetic …

Abstract Hypoxia-inducible factor-1 (HIF-1), an essential promoter of tumor progression, has
attracted increasing attention as a therapeutic target. In addition to hypoxic cellular …

Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy.
Standard therapeutic approaches provide modest improvement in progression-free and …

A brain drug delivery system for glioma chemotherapy based on transferrin and cell-
penetrating peptide dual-functioned liposome, Tf/TAT-lip, was made and evaluated with …

Effective delivery of nanoparticles to the target site is necessary for successful biomedical
applications. Inefficient targeting is a major concern for nanomedicines in cancer therapy …

A major obstacle for chemotherapeutics in Glioblastoma (GB) is to reach the tumour cells
due to the presence of the blood-brain barrier (BBB) and chemoresistance of anticancer …