The purpose of this study was to develop an efficient dual-ligand based liposomal drug
delivery system with targeting specificity as well as properties that would kill melanoma cells …

Cancer chemotherapy is mainly based on the use of cytotoxic compounds that often affect
other tissues, generating serious side effects which deteriorate the quality of life of patients …

SN38 is the active metabolite of irinotecan with 1000-fold greater cytotoxicity compared to
the parent drug. Despite the potential, its application as a drug is still seriously limited due to …

Hybrid nanoparticles consisting of lipids and the biodegradable polymer, poly (D, L-lactide-
co-glycolide)(PLGA), were developed for the targeted delivery of the anticancer drug …

Matrix metalloproteinases (MMPs), mostly abundant in the tumor extracellular matrix (ECM),
tumor cells, and tumor vasculatures, are closely correlated with tumor progression and …

Glioblastoma (GBM) is the most aggressive tumor type in the central nervous system. Both
tumor-targeting drug delivery and combination therapy of multiple therapeutic agents with …

Therapeutic outcome for the treatment of glioma was often limited due to the non-targeted
nature and low permeability of drugs across the blood-brain barrier (BBB). An ideal glioma …

The integrins αvβ3 play a very imperative role in angiogenesis and are overexpressed in
endothelial cells of the tumour. Recent years have witnessed huge exploration in the field of …

Glioblastoma (GB) is an aggressive cancer with high microvascular proliferation, resulting in
accelerated invasion and diffused infiltration into the surrounding brain tissues with very low …

Intratumoral drug delivery (IT) is an inherently appealing approach for concentrating toxic
chemotherapies at the site of action. However, for most chemotherapies, poor tumor …