Biosensors that detect and convert biological reactions to a measurable signal have gained
much attention in recent years. Between 1950 and 2017, more than 150,000 papers have …

Biomolecular recognition is versatile, specific, and high affinity, qualities that have motivated
decades of research aimed at adapting biomolecules into a general platform for molecular …

ABSTRACT Immunoglobulin G1 (IgG1) is the most abundant circulating human antibody
and also the scaffold for many therapeutic monoclonal antibodies (mAbs). The destruction of …

Abstract The programmed death-1 (PD-1) molecule is involved in peripheral tolerance and
in the immune escape mechanisms during chronic viral infections and cancer. PD-1 …

The maximum achievable accuracy of in silico models depends on the quality of the
experimental data. Consequently, experimental uncertainty defines a natural upper limit to …

Built on the principle of specific biological-recognition measurements coupled with a signal
transducer, surface-plasmon-resonance (SPR)-biosensor technology has developed over …

The acquisition of reliable kinetic parameters for the characterization of biomolecular
interactions is an important component of the drug discovery and development process …

The detection and characterization of fragment binding requires the use of technologies with
extreme sensitivity to observe the binding interactions of low-affinity and low-molecular …

Highlights•Linear scaling between binding-and activation energies occurs for some enzyme
reactions.•This is particularly seen for heterogeneous biocatalysis involving insoluble …

We took a different approach to reviewing the commercial biosensor literature this year by
inviting 22 biosensor users to serve as a review committee. They set the criteria for what to …