This paper emphasizes the importance of rigorous validation as a crucial, integral
component of Quantitative Structure Property Relationship (QSPR) model development. We …

In the current chapter, we review approaches to the identification of the residues forming the
binding sites for agonists, antagonists, and allosteric modulators in the family of aminergic G …

The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets
for neuropsychiatric and endocrine disorders. Most clinically approved and investigational …

The dopamine (DA) D1 receptor is the most highly expressed DA receptor subtype among
the DA receptor family. Although the first DA D1 receptor selective ligand SCH‐23390 (1) …

The aminergic family of G protein-coupled receptors (GPCRs) plays an important role in
various diseases and represents a major drug discovery target class. Structure …

Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we
developed subtype selective dopamine receptor ligands of types 1a, c, 2a, and 3a …

On the basis of previous work on dopaminergic partial agonists of type 1 and 2, disubstituted
ferrocenes are presented as valuable arene bioisosteres. Because substituents at the distal …

The dopaminergic system is one of the most important neurotransmitter systems in the
central nervous system (CNS). It acts mainly by activation of the D1-like receptor family at the …

A large number of natural, synthetic and environmental chemicals are capable of disrupting
the endocrine systems of experimental animals, wildlife and humans. These so-called …

A relatively new strategy in drug discovery is the development of dual acting ligands. These
molecules are potentially able to interact at two orthosteric binding sites of a heterodimer …