The role of cytochrome P450s in insect toxicology and resistance
Insect cytochrome P450 monooxygenases (P450s) perform a variety of important
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …
Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Role of cytochrome P450 enzymes in plant stress response
BA Pandian, R Sathishraj, M Djanaguiraman… - Antioxidants, 2020 - mdpi.com
Cytochrome P450s (CYPs) are the largest enzyme family involved in NADPH-and/or O2-
dependent hydroxylation reactions across all the domains of life. In plants and animals …
dependent hydroxylation reactions across all the domains of life. In plants and animals …
Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
Critical enzyme reactions in aromatic catabolism for microbial lignin conversion
The application of microbes to valorize aromatic compounds derived from the abundant
plant biopolymer lignin is a rapidly developing area of research that may ultimately enable …
plant biopolymer lignin is a rapidly developing area of research that may ultimately enable …
Reliably assessing the electronic structure of cytochrome P450 on today's classical computers and tomorrow's quantum computers
An accurate assessment of how quantum computers can be used for chemical simulation,
especially their potential computational advantages, provides important context on how to …
especially their potential computational advantages, provides important context on how to …
[HTML][HTML] Diversity and evolution of the P450 family in arthropods
The P450 family (CYP genes) of arthropods encodes diverse enzymes involved in the
metabolism of foreign compounds and in essential endocrine or ecophysiological functions …
metabolism of foreign compounds and in essential endocrine or ecophysiological functions …
Cytochrome P450 enzymes in fungal natural product biosynthesis
X Zhang, J Guo, F Cheng, S Li - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …
terpenoids and their hybrids contribute significantly to the chemical space of total natural …
Recent advances in triterpenoid pathway elucidation and engineering
S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …
[HTML][HTML] The gut microbiome: an orchestrator of xenobiotic metabolism
SL Collins, AD Patterson - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism.
The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter …
The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter …