Abstract Purpose of Review While aeroallergens are a well-established trigger of asthma
and allergic rhinitis, their role in allergic skin diseases such as atopic dermatitis and chronic …

Bronchial asthma is one of the most common chronic conditions in pediatric practice, with
increasing prevalence hampered by poor socioeconomic impacts, leading to major public …

Asthma is classically described as having either a type 2 (T2) eosinophilic phenotype or a
non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation …

Background Wheezing in early life is associated with asthma in adulthood; however, the
determinants of wheezing trajectories and their associations with asthma and lung function …

Background Poor adherence to inhaled corticosteroids (ICSs) and overuse of short-acting
beta 2-agonists (SABAs) are associated with increased asthma morbidity. Objective To …

Background With the introduction of different targeted therapies for type 2 (T2)-high asthma,
there is an urgent need for markers to guide the choice of treatment. T2-high asthma …

Although bronchiectasis pathophysiology has been historically understood around the
presence of airway neutrophilic inflammation, recent experiences are consistent with the …

Patients with severe refractory asthma present a challenging clinical conundrum for
practicing clinicians. Biologics that target key mediators in the type 2 inflammation cascade …

Background Although clinical features of type 2 inflammation have been associated with
poorer longitudinal outcomes in preschool children with recurrent wheezing, it remains …

Introduction Asthma is characterized by enhanced airway contractility and remodeling where
airway smooth muscle (ASM) plays a key role, modulated by inflammation. Understanding …