“Green” strategies to build up novel organic nanocarriers with bioperformance are modern
trends in nanotechnology. In this way, the valorization of bio-wastes and the use of living …

Ophthalmic disorders are amid the most common pathologies worldwide. In this regard,
hyaluronan (HA) has gained widespread use in eye surgeries and treatment of eye …

Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the
ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation …

Currently, ocular inserts and nanoparticles have received much attention due to the limited
bioavailability of conventional eye preparations and the toxicity problems of systemic drug …

The aim was to design and evaluate a chitosan-based conjugate providing high
mucoadhesiveness and antibacterial activity for ocular infections treatment. Chitosan was …

Despite their conventional and widespread use, oral and intravenous routes of drug
administration face several limitations. In particular, orally administered drugs undergo …

Proteins and peptides are potential therapeutic agents, but their physiochemical properties
make their use as drug substances challenging. Hydrogels are hydrophilic polymeric …

Photoreceptors (PRs), as the most abundant and light-sensing cells of the neuroretina, are
responsible for converting light into electrical signals that can be interpreted by the brain. PR …

Dry eye disease (DED) is a dynamic and complex disease that can cause significant
damage to the ocular surface and discomfort, compromising the patient's quality of life …

Brinzolamide is an effective carbonic anhydrase inhibitor widely used in glaucoma therapy
but limits its application due to inadequate aqueous solubility and permeability. The aim of …