Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

D Jain, P Chaudhary, N Varshney… - Journal of …, 2021 - Wiley Online Library
Smoking a cigarette generates over 4000 chemicals that have a deleterious impact on each
part of the human body. It produces three main severe effects on the liver organ: oncogenic …

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

V Schijns, A Fernández‐Tejada… - Immunological …, 2020 - Wiley Online Library
Therapeutic vaccination offers great promise as an intervention for a diversity of infectious
and non‐infectious conditions. Given that most chronic health conditions are thought to have …

[HTML][HTML] Novel Immunoinformatics Approaches to Design Multi-epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein

RK Pandey, TK Bhatt, VK Prajapati - Scientific reports, 2018 - nature.com
Malaria fever has been pervasive for quite a while in tropical developing regions causing
high morbidity and mortality. The causal organism is a protozoan parasite of genus …

Designing cell lines for viral vaccine production: Where do we stand?

Y Genzel - Biotechnology journal, 2015 - Wiley Online Library
Established animal cells, such as Vero, Madin Darby canine kidney (MDCK) or chicken
embryo fibroblasts (CEFs), are still the main cell lines used for viral vaccine production …

Development of vaccines to treat opioid use disorders and reduce incidence of overdose

M Pravetoni, SD Comer - Neuropharmacology, 2019 - Elsevier
Vaccines offer a promising therapeutic strategy to treat substance use disorders (SUD).
Vaccines have shown extensive preclinical proof of selectivity, safety, and efficacy against …

Nicotine and tobacco as substances of abuse in children and adolescents

LM Siqueira, SA Ryan, PK Gonzalez, SW Patrick… - …, 2017 - publications.aap.org
Nicotine is the primary pharmacologic component of tobacco, and users of tobacco products
seek out its effects. The highly addictive nature of nicotine is responsible for its widespread …

[HTML][HTML] Designs of antigen structure and composition for improved protein-based vaccine efficacy

K Saylor, F Gillam, T Lohneis, C Zhang - Frontiers in Immunology, 2020 - frontiersin.org
Today, vaccinologists have come to understand that the hallmark of any protective immune
response is the antigen. However, it is not the whole antigen that dictates the immune …

[HTML][HTML] Nanoparticle delivery systems for substance use disorder

V Kasina, RJ Mownn, R Bahal, GC Sartor - Neuropsychopharmacology, 2022 - nature.com
Innovative breakthroughs in nanotechnology are having a substantial impact in healthcare,
especially for brain diseases where effective therapeutic delivery systems are desperately …

Adjuvants for vaccines to drugs of abuse and addiction

CR Alving, GR Matyas, O Torres, R Jalah, Z Beck - Vaccine, 2014 - Elsevier
Immunotherapeutic vaccines to drugs of abuse, including nicotine, cocaine, heroin,
oxycodone, methamphetamine, and others are being developed. The theoretical basis of …

[HTML][HTML] An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania …

MAA Khan, JQ Ami, K Faisal, R Chowdhury, P Ghosh… - Parasites & vectors, 2020 - Springer
Background Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …