CD44: A multifunctional mediator of cancer progression
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …
The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma
J Baglieri, DA Brenner, T Kisseleva - International journal of molecular …, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks
effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury …
effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury …
[HTML][HTML] Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis
I Fabregat, D Caballero-Díaz - Frontiers in oncology, 2018 - frontiersin.org
The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …
different cellular processes that are essential for tissue and organ homeostasis. In the case …
Role of epithelial to mesenchymal transition in hepatocellular carcinoma
G Giannelli, P Koudelkova, F Dituri, W Mikulits - Journal of hepatology, 2016 - Elsevier
The epithelial to mesenchymal transition (EMT) is a multistep biological process whereby
epithelial cells change in plasticity by transient de-differentiation into a mesenchymal …
epithelial cells change in plasticity by transient de-differentiation into a mesenchymal …
Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
Programmed death ligand 1 expression in hepatocellular carcinoma: relationship with clinical and pathological features
J Calderaro, B Rousseau, G Amaddeo, M Mercey… - Hepatology, 2016 - journals.lww.com
In patients with hepatocellular carcinoma (HCC) receiving sorafenib, drug resistance is
common. HCC develops in a microenvironment enriched with extracellular matrix proteins …
common. HCC develops in a microenvironment enriched with extracellular matrix proteins …
Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
L Wei, D Lee, CT Law, MS Zhang, J Shen… - Nature …, 2019 - nature.com
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC).
However, the development of drug resistance is common. By using genome-wide …
However, the development of drug resistance is common. By using genome-wide …
Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: the “Anticipate” study
In patients with compensated advanced chronic liver disease (cACLD), the presence of
clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears …
clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears …
[HTML][HTML] Recent advances in repurposing disulfiram and disulfiram derivatives as copper-dependent anticancer agents
V Kannappan, M Ali, B Small, G Rajendran… - Frontiers in Molecular …, 2021 - frontiersin.org
Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates
the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based …
the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based …
Molecular bases of drug resistance in hepatocellular carcinoma
The poor outcome of patients with non-surgically removable advanced hepatocellular
carcinoma (HCC), the most frequent type of primary liver cancer, is mainly due to the high …
carcinoma (HCC), the most frequent type of primary liver cancer, is mainly due to the high …