Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

All members of the Borrelia genus that have been examined harbour a linear chromosome
that is about 900 kbp in length, as well as a plethora of both linear and circular plasmids in …

The Lyme disease spirochete persists in nature through cycles between ticks and
vertebrates. Although the spirochete interacts with numerous, distinct tissues and …

Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …

The annual incidence of Lyme disease, caused by tick-transmitted Borreliella burgdorferi, is
estimated to be at least 476,000 cases in the United States and many more worldwide. Ten …

Lyme disease is the most common vector-borne disease in the northern hemisphere and is
caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Lyme borreliae infect …

Borrelia burgdorferi sensu lato causes Lyme borreliosis in a variety of animals and humans.
These atypical bacterial pathogens are maintained in a complex enzootic life cycle that …

Glycerol utilization as a carbohydrate source by Borreliella burgdorferi, the Lyme disease
spirochete, is critical for its successful colonization and persistence in the tick vector. The …

Prokaryote restriction modification (RM) systems serve to protect bacteria from potentially
detrimental foreign DNA. Recent evidence suggests that DNA methylation by the …