N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an
important role in learning and memory, and are critical for spatial memory. These receptors …

One of the current problems in medicine research is the development of safe drugs for the
treatment of neurological disorders. Furthermore, there is a close relationship between the …

Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …

Background N-methyl-D-aspartate receptor (NMDAR)-mediated neurotransmission is vital
for learning and memory. Hypofunction of NMDAR has been reported to play a role in the …

Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative condition. The
complex pathology of this disease includes oxidative stress, metal deposition, formation of …

Mitochondrial structural and functional alterations appear to play to an important role in the
pathogenesis of Alzheimer's disease (AD). In the present study, we used a quantitative …

OBJECTIVE: To study the effects of green tea extract administration on age-related cognition
in young and old male Wistar rats. METHODS: Young and old rats were orally administered …

Exercise enhances general health. However, its effects on neurodegeneration are
controversial, and the molecular pathways in the brain involved in this enhancement are …

Diabetes Mellitus (DM) and Alzheimer's disease (AD) are two prevalent diseases in modern
societies, which are caused mainly by current lifestyle, aging and genetic alterations. It has …

Dementia has become an all-important disease because the population is aging rapidly and
the cost of health care associated with dementia is ever increasing. In addition to cognitive …