[HTML][HTML] Current therapy and drug resistance in metastatic castration-resistant prostate cancer

M Cai, XL Song, XA Li, M Chen, J Guo, DH Yang… - Drug Resistance …, 2023 - Elsevier
Castration-resistant prostate cancer (CRPC), especially metastatic castration-resistant
prostate cancer (mCRPC) is one of the most prevalent malignancies and main cause of …

Immunotherapy for prostate cancer: a current systematic review and patient centric perspectives

L Rehman, MH Nisar, W Fatima, A Sarfraz… - Journal of clinical …, 2023 - mdpi.com
Prostate cancer is the most commonly diagnosed cancer in men worldwide, making up 21%
of all cancer cases. With 345,000 deaths per year owing to the disease, there is an urgent …

AMG 509 (xaluritamig), an anti-STEAP1 XmAb 2+ 1 T-cell redirecting immune therapy with avidity-dependent activity against prostate cancer

O Nolan-Stevaux, C Li, L Liang, J Zhan, J Estrada… - Cancer Discovery, 2024 - AACR
The tumor-associated antigen STEAP1 is a potential therapeutic target that is expressed in
most prostate tumors and at increased levels in metastatic castration-resistant prostate …

[HTML][HTML] Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer

E Sayar, RA Patel, IM Coleman, MP Roudier, A Zhang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate
cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic …

Prostate-Specific Membrane Antigen: Gateway to Management of Advanced Prostate Cancer

LM Unterrainer, J Calais… - Annual Review of …, 2024 - annualreviews.org
Prostate-specific membrane antigen (PSMA) as a transmembrane protein is overexpressed
by prostate cancer (PC) cells and is accessible for binding antibodies or low-molecular …

Emerging Immunotherapy Approaches for Treating Prostate Cancer

L Meng, Y Yang, A Mortazavi, J Zhang - International journal of molecular …, 2023 - mdpi.com
Immunotherapy has emerged as an important approach for cancer treatment, but its clinical
efficacy has been limited in prostate cancer compared to other malignancies. This review …

[HTML][HTML] Evolution of radiological treatment response assessments for cancer immunotherapy: from iRECIST to radiomics and artificial intelligence

N Kim, ES Lee, SE Won, M Yang, AJ Lee… - Korean Journal of …, 2022 - ncbi.nlm.nih.gov
Immunotherapy has revolutionized and opened a new paradigm for cancer treatment. In the
era of immunotherapy and molecular targeted therapy, precision medicine has gained …

A multicentric, single arm, open-label, phase I/II study evaluating PSMA targeted radionuclide therapy in adult patients with metastatic clear cell renal cancer (PRadR)

D Kryza, A Vinceneux, AS Bidaux, G Garin, D Tatu… - BMC cancer, 2024 - Springer
Background Despite advancements in managing metastatic clear cell renal carcinoma
(mccRCC) through antiangiogenic tyrosine kinase inhibitors and immunotherapy, there …

[HTML][HTML] Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo

A Yehya, F Ghamlouche, A Zahwe, Y Zeid… - Cancer Drug …, 2022 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men
globally. Despite improvements in the diagnosis and treatment of PCa, a significant …

PSMA-based therapeutics for prostate cancer

PV Stamatakos, C Fragkoulis, A Leventi… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction The prostate cancer (PCa) consist the most frequently diagnosed
malignancy of urogenital system in males. Traditionally, treatment of localized PCa was …