Descending control of pain

MJ Millan - Progress in neurobiology, 2002 - Elsevier
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Neural mechanism underlying acupuncture analgesia

ZQ Zhao - Progress in neurobiology, 2008 - Elsevier
Acupuncture has been accepted to effectively treat chronic pain by inserting needles into the
specific “acupuncture points”(acupoints) on the patient's body. During the last decades, our …

[HTML][HTML] Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain

JM Bráz, R Sharif-Naeini, D Vogt, A Kriegstein… - Neuron, 2012 - cell.com
Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia
and spontaneous pain. Because symptoms are often unresponsive to conventional methods …

Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models

TL Yaksh - Trends in pharmacological sciences, 1999 - cell.com
Much research has been undertaken in the field of pain in an attempt to find an effective
treatment. Insights into the underlying mechanisms of pain have been gained from studies …

The nature and course of sensory changes following spinal cord injury: predictive properties and implications on the mechanism of central pain

G Zeilig, S Enosh, D Rubin-Asher, B Lehr, R Defrin - Brain, 2012 - academic.oup.com
Central pain below the injury level after spinal cord injury is excruciating, chronic and
resistive to treatment. Animal studies suggest that pretreatment may prevent central pain, but …

Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration?

J Vaquero, M Zurita, S Oya, M Santos - Neuroscience letters, 2006 - Elsevier
Recent studies showed the therapeutic effect of bone marrow stromal cells (BMSC) after
spinal cord injury (SCI). In the present study, we compared the effect of systemic and local …

Methods for behavioral testing of spinal cord injured rats

J Šedý, L Urdzíková, P Jendelová, E Syková - … & Biobehavioral Reviews, 2008 - Elsevier
Behavioral outcome in rats with spinal cord injury (SCI) is the most important factor for
evaluating the extent of injury and treatment efficacy. For this purpose, a number of …

Experimental spinal cord injury and behavioral tests in laboratory rats

RU Ahmed, M Alam, YP Zheng - Heliyon, 2019 - cell.com
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …

Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement

PH Lin, Q Dong, SY Chew - Materials Advances, 2021 - pubs.rsc.org
Central nervous system (CNS) pathologies, such as stroke and spinal cord injury, remain
debilitating issues due to the inhibitory environment in the CNS. Many research works have …

Spinal cord injury: a model of central neuropathic pain

RP Yezierski - Neurosignals, 2005 - karger.com
The condition of pain after spinal cord injury (SCI) affects the life quality of nearly 70% of
individuals with SCI. Clinical studies over the past decade have provided important insights …