The expanding array of HIV broadly neutralizing antibodies
LE McCoy - Retrovirology, 2018 - Springer
A large array of broadly neutralizing antibodies (bnAbs) against HIV have been isolated and
described, particularly in the last decade. This continually expanding array of bnAbs has …
described, particularly in the last decade. This continually expanding array of bnAbs has …
Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1
Infusion of broadly neutralizing antibodies (bNAbs) has shown promise as an alternative to
anti-retroviral therapy against HIV. A key challenge is to suppress viral escape, which is …
anti-retroviral therapy against HIV. A key challenge is to suppress viral escape, which is …
Development of protein-and peptide-based HIV entry inhibitors targeting gp120 or gp41
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and
mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant …
mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant …
Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys
A Pegu, L Xu, ME DeMouth, G Fabozzi, K March… - Cell reports, 2022 - cell.com
Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the
treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads to emergence of …
treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads to emergence of …
AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges
MR Gardner, CH Fellinger, LM Kattenhorn… - Science translational …, 2019 - science.org
A number of simian and simian human immunodeficiency viruses (SIV and SHIV,
respectively) have been used to assess the efficacy of HIV-1 vaccine strategies. Among …
respectively) have been used to assess the efficacy of HIV-1 vaccine strategies. Among …
Next-generation bNAbs for HIV-1 cure strategies
AI Schriek, YLT Aldon, MJ van Gils, SW de Taeye - Antiviral research, 2023 - Elsevier
Despite the ability to suppress viral replication using anti-retroviral therapy (ART), HIV-1
remains a global public health problem. Curative strategies for HIV-1 have to target and …
remains a global public health problem. Curative strategies for HIV-1 have to target and …
Neutralizing antibodies for HIV-1 prevention
B Julg, DH Barouch - Current opinion in HIV and AIDS, 2019 - journals.lww.com
Encouraging results from preclinical and clinical studies support the development of bNAbs
for prevention and a number of antibodies with exceptional breadth and potency are …
for prevention and a number of antibodies with exceptional breadth and potency are …
Small molecule HIV-1 attachment inhibitors: discovery, mode of action and structural basis of inhibition
YT Lai - Viruses, 2021 - mdpi.com
Viral entry into host cells is a critical step in the viral life cycle. HIV-1 entry is mediated by the
sole surface envelope glycoprotein Env and is initiated by the interaction between Env and …
sole surface envelope glycoprotein Env and is initiated by the interaction between Env and …
Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection
J Dias, G Fabozzi, S Fourati, X Chen, C Liu… - Nature …, 2024 - nature.com
Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating
virus neutralization and antiviral effector functions through their Fab and Fc domains …
virus neutralization and antiviral effector functions through their Fab and Fc domains …
Accurate prediction for antibody resistance of clinical HIV-1 isolates
Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env)
have promising utility in prevention and treatment of HIV-1 infection, and several are …
have promising utility in prevention and treatment of HIV-1 infection, and several are …