The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark
of many chronic degenerative diseases. By using a model of acute peritoneal inflammation …

Appropriate control of leukocyte recruitment and activation is a fundamental requirement for
competent host defense and resolving inflammation. A pivotal event that defines the …

Members of the suppressor of cytokine signaling (SOCS) family are potentially key
physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether …

Background & Aims: Viral hepatitis infection, which is a major cause of liver fibrosis, is
associated with activation of innate immunity. However, the role of innate immunity in liver …

Cytokine receptors, which exist in membrane-bound and soluble forms, bind their ligands
with comparable affinity. Although most soluble receptors are antagonists and compete with …

The central role of T cell activation in hepatocellular injury has been well documented. In this
article, we provide evidence suggesting that T cells may also play a protective role in liver …

Signal Transducers and Activators of Transcription (STATs) are a family of transcription
factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory …

Summary The cytokine interleukin-22 (IL-22) is primarily expressed by T helper 17 (Th17)
CD4+ T cells and is highly upregulated during chronic inflammatory diseases. IL-22 receptor …