Obesity is a risk factor for cardiovascular disease (CVD). However, clinical research has
revealed a paradoxically protective role for obesity in patients with chronic diseases …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …

Abstract Fennel (Foeniculum vulgare Mill), a member of the Apiaceae family
(Umbelliferaceae), is a hardy and perennial herb, with grooved stems, intermittent leaves …

We address advances in the understanding of myometrial physiology, focusing on excitation
and the effects of gestation on ion channels and their relevance to labor. This review moves …

Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological
impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic …

As a first step towards the production of functional cell sheets applicable for the regeneration
of gut muscle layer, microstructured bacterial cellulose (mBC) was assessed for its ability to …

The uricosuric drug benzbromarone, widely used for treatment of gout, hyperpolarizes the
membrane potential of airway smooth muscle cells, but how it works remains unknown. Here …

Background: The Kv7 (KCNQ) subfamily of voltage-gated potassium channels consists of 5
members (Kv7. 1-5) each showing characteristic tissue distribution and physiological roles …

Hypertension is a prevalent health problem inducing many organ damages. The
pathogenesis of hypertension involves a complex integration of different organ systems …