Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and
sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for …

Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically …

Ubiquitous in nature, cilia and flagella comprise nearly identical structures with similar
functions. The most obvious example of the latter is motility: driving movement of the …

Recent studies have revealed unexpected connections between the mammalian Hedgehog
(Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that …

Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of
spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase …

Cerebello-oculo-renal syndrome (CORS), also called Joubert syndrome type B, and Meckel
(MKS) syndrome belong to the group of developmental autosomal recessive disorders that …

Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …

Meckel-Gruber syndrome (MKS) is a genetically heterogeneous, neonatally lethal
malformation and the most common form of syndromic neural tube defect (NTD). To date …

Abstract Joubert syndrome (JBTS; OMIM 213300) is a rare, autosomal recessive disorder
characterized by a specific congenital malformation of the hindbrain and a broad spectrum …