Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in
neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative …

Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective
efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18 …

The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …

Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Alzheimer's disease (AD) is a neurodegenerative disease with amyloid beta (Aβ) deposition
and intracellular neurofibrillary tangles (NFTs) as its characteristic pathological changes …

Simple Summary Glioblastoma multiforme (GBM) is the most aggressive tumor type in the
central nervous system. Hypoxia, defined as a lack of sufficient oxygen in tissues, is the most …