Neurodegenerative disorders and gut-brain interactions

A Singh, TM Dawson, S Kulkarni - The Journal of clinical …, 2021 - Am Soc Clin Investig
Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

Targeting gut microbiota to alleviate neuroinflammation in Alzheimer's disease

VTT Nguyen, K Endres - Advanced drug delivery reviews, 2022 - Elsevier
The gut microbiota came into focus within the last years regarding being associated with or
even underlying neuropsychiatric diseases. The existence of the gut-brain-axis makes it …

The gut–immune–brain axis: an important route for neuropsychiatric morbidity in inflammatory bowel disease

RK Masanetz, J Winkler, B Winner, C Günther… - International Journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis
(UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both …

Inflammatory bowel disease: a potential pathogenic factor of Alzheimer's disease

D Wang, X Zhang, H Du - Progress in Neuro-Psychopharmacology and …, 2022 - Elsevier
Alzheimer's disease (AD) is a central nervous system disease characterised by
degenerative cognitive dysfunction and memory loss. In a society where the global …

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease

R Kaneko, A Matsui, M Watanabe, Y Harada… - Inflammation and …, 2023 - Springer
Background Alzheimer's disease (AD) is one of the neurodegenerative diseases and
characterized by the appearance and accumulation of amyloid-β (Aβ) aggregates and …

Inflammatory bowel disease and risk of dementia: An updated meta-analysis

N Liu, Y Wang, L He, J Sun, X Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Background Growing evidence suggests that inflammatory bowel disease (IBD) and
dementia share pathological mechanisms and pathogenic risk factors. However, the …

[HTML][HTML] Protective effects of CCL01 against Aβ-induced neurotoxicity in 5xFAD transgenic mouse model of Alzheimer's disease

IG Ju, SY Son, S Lee, H Im, E Huh, H Eo… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common dementia characterized by the excessive
accumulation of amyloid-beta (Aβ) and tau aggregates, as well as neuronal damage and …

Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose …

J Homolak, A Babic Perhoc, A Knezovic… - …, 2022 - karger.com
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic
dysfunction, systemic, and neuroinflammation in Alzheimer's disease. Dysfunctional …

A class I HDAC inhibitor rescues synaptic damage and neuron loss in APP-transfected cells and APP/PS1 mice through the GRIP1/AMPA pathway

Y Han, L Chen, J Liu, J Chen, C Wang, Y Guo, X Yu… - Molecules, 2022 - mdpi.com
As a neurodegenerative disease, Alzheimer's disease (AD) seriously affects the health of
older people. Changes in synapses occur first over the course of the disease, perhaps even …

Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics

J Homolak - Advances in Protein Chemistry and Structural Biology, 2023 - Elsevier
Neurodegenerative diseases are a group of age-related disorders characterized by a
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …