Alternative poly (A) site selection in complex transcription units: means to an end?
G Edwalds-Gilbert, KL Veraldi… - Nucleic acids …, 1997 - academic.oup.com
Many genes have been described and characterized which result in alternative
polyadenylation site use at the 3′-end of their mRNAs based on the cellular environment …
polyadenylation site use at the 3′-end of their mRNAs based on the cellular environment …
Delineating the structural blueprint of the pre-mRNA 3′-end processing machinery
Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.
S Connelly, JL Manley - Genes & development, 1988 - genesdev.cshlp.org
Polyadenylation of pre-mRNAs requires the conserved hexanucleotide AAUAAA, as well as
sequences located downstream from the poly (A) addition site. The role of these sequences …
sequences located downstream from the poly (A) addition site. The role of these sequences …
3′ UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts
N Spies, CB Burge, DP Bartel - Genome research, 2013 - genome.cshlp.org
Variation in protein output across the genome is controlled at several levels, but the relative
contributions of different regulatory mechanisms remain poorly understood. Here, we …
contributions of different regulatory mechanisms remain poorly understood. Here, we …
Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro
MD Sheets, SC Ogg, MP Wickens - Nucleic acids research, 1990 - academic.oup.com
Three sequences in the vicinity of poly (A) addition sites are conserved among vertebrate
mRNAs. We analyze the effects of single base changes in each position of AAUAAA and in …
mRNAs. We analyze the effects of single base changes in each position of AAUAAA and in …
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.
I KoVESDI, R Reichel… - Proceedings of the …, 1987 - National Acad Sciences
A product of the adenovirus gene E1A is responsible for the stimulation of transcription from
six viral promoters as well as at least two cellular promoters. We have detected a HeLa cell …
six viral promoters as well as at least two cellular promoters. We have detected a HeLa cell …
Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation
A Gil, NJ Proudfoot - Cell, 1987 - cell.com
We previously demonstrated that a critical 35 bp region 3'of the AAUAAA is required for
rabbit (3-globln mRNA 3'end formation. Recently, we synthesized and tested sequence …
rabbit (3-globln mRNA 3'end formation. Recently, we synthesized and tested sequence …
Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences
S Carswell, JC Alwine - Molecular and Cellular Biology, 1989 - Am Soc Microbiol
The late polyadenylation signal of simian virus 40 functions with greater efficiency than the
early polyadenylation signal, in turn affecting steady-state mRNA levels. Two …
early polyadenylation signal, in turn affecting steady-state mRNA levels. Two …
Formation of the 3′ end of U1 snRNA requires compatible snRNA promoter elements
N Hernandez, AM Weiner - Cell, 1986 - cell.com
Ul and U2 snRNAs an? thought to be transcribed by RNA polymerase II. A conserved
sequence known as the 3'box is located just downstream from the snRNA coding region and …
sequence known as the 3'box is located just downstream from the snRNA coding region and …
[HTML][HTML] The 3'-flanking sequence of the bovine growth hormone gene contains novel elements required for efficient and accurate polyadenylation.
EC Goodwin, FM Rottman - Journal of Biological Chemistry, 1992 - Elsevier
In addition to the conserved AAUAAA hexanucleotide, GU-and U-rich sequences in the 3'-
flanking region are thought to be critical for efficient polyadenylation. The 3'-flanking …
flanking region are thought to be critical for efficient polyadenylation. The 3'-flanking …