Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: A systematic review and meta-analysis

XF Zhang, XX Guan, YJ Tang, JF Sun, XK Wang… - European journal of …, 2021 - Springer
Purpose Probiotics have been reported to be beneficial for inflammatory bowel disease
(IBD), but the types, number of strains, dosage, and intervention time of probiotics used …

The enteric nervous system in gastrointestinal disease etiology

AM Holland, AC Bon-Frauches, D Keszthelyi… - Cellular and Molecular …, 2021 - Springer
A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial

BG Feagan, S Danese, EV Loftus, S Vermeire… - The Lancet, 2021 - thelancet.com
Background The global prevalence of ulcerative colitis is increasing, and induction and
maintenance of remission is a crucial therapeutic goal. We assessed the efficacy and safety …

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

P Zhao, X Xia, X Xu, KKC Leung, A Rai, Y Deng… - Nature …, 2021 - nature.com
A key challenge for the effective treatment of gastrointestinal diseases including
inflammatory bowel disease is to develop an orally administered drug delivery system …

Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent …

Q Li, Y Cui, B Xu, Y Wang, F Lv, Z Li, H Li… - Pharmacological …, 2021 - Elsevier
As an effective drug against acute enteritis diarrhea, Gegen Qinlian decoction (GQD) has a
history of 2000 years. However, the potential molecular mechanism through which GQD …

Atmosphere-inspired multilayered nanoarmor with modulable protection and delivery of Interleukin-4 for inflammatory microenvironment modulation

X Ge, J Hu, Y Peng, Z Zeng, D He, X Li, Y Chen, G Luo… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) has been closely associated with immune disorders and
excessive M1 macrophage activation, which can be reversed by the M2-polarizing effect of …

[HTML][HTML] Herba Origani alleviated DSS-induced ulcerative colitis in mice through remolding gut microbiota to regulate bile acid and short-chain fatty acid metabolisms

Z Yu, D Li, H Sun - Biomedicine & Pharmacotherapy, 2023 - Elsevier
This study aimed to investigate the protective effect of Herba Origani, the dried whole herb of
Origanum vulgare L., on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice and …

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

L Ge, S Liu, S Li, J Yang, G Hu, C Xu… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn's
disease (CD), is an autoimmune gastrointestinal disease characterized by chronic …

Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota

QX Huang, JL Liang, CH Yang, K Li, MT Niu, JX Fan… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

H Hadji, K Bouchemal - Advanced Drug Delivery Reviews, 2022 - Elsevier
The complex pathogenesis of inflammatory bowel disease (IBD) explains the several
hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to …