Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure
Y Peng, Y Lin, K Deng, J Shen, Y Cui, J Liu… - Journal of Assisted …, 2023 - Springer
Purpose To investigate the genetic causes of polyspermy and total fertilization failure (TFF)
in two independent male patients suffering from male infertility. Methods …
in two independent male patients suffering from male infertility. Methods …
Inhibition of neddylation disturbs zygotic genome activation through histone modification change and leads to early development arrest in mouse embryos
G Yang, Y Wang, S Hu, J Chen, L Chen, H Miao… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Post-translational modification and fine-tuned protein turnover are of great importance in
mammalian early embryo development. Apart from the classic protein degradation …
mammalian early embryo development. Apart from the classic protein degradation …
Glucose metabolism disorder related to follicular fluid exosomal miR-122-5p in cumulus cells of endometriosis patients
J Zhang, K Li, L Gao, P Zhu, L Shu, L Cai… - …, 2024 - rep.bioscientifica.com
MiR-122-5p, high expression in follicular fluid exosomes of patients with endometriosis,
impairs the glucose metabolism function of cumulus cells and may further impair oocyte …
impairs the glucose metabolism function of cumulus cells and may further impair oocyte …
Inhibition of neddylation causes early developmental arrestment in mouse embryo because of the zygotic genome activation failure
G Yang, S Hu, J Chen, L Chen, H Miao, N Li, H Luo… - 2023 - researchsquare.com
Background Maternal protein degradation in mammalian preimplantation embryos has yet to
be fully understood. One major pathway is the ubiquitin-proteasome system. Recently, new …
be fully understood. One major pathway is the ubiquitin-proteasome system. Recently, new …