Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Members of the PGC‐1 family of coactivators have been revealed as key players in the
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …

Aims/hypothesis While it is well known that diet-induced obesity causes insulin resistance,
the precise mechanisms underpinning the initiation of insulin resistance are unclear. To …

Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

Cachexia affects the majority of cancer patients, with currently no effective treatments.
Cachexia is defined by increased fatigue and loss of muscle function resulting from muscle …

High–fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation,
particularly in white adipose tissue (WAT). However, insulin insensitivity is apparent within …

The main estrogens: estradiol, estrone, and their acyl-esters have been studied essentially
related to their classical estrogenic and pharmacologic functions. However, their main effect …

Recent controversy regarding the therapeutic potential of curcumin indicates the challenges
to research in this field. Here, we highlight the investigations of curcumin and other plant …