Background The long-term negative effects of adverse childhood experiences (ACEs) and
their impact on physical and mental health has been widely studied. However, research …

Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward
guided behavior as well as drug dependance, still remains elusive. Recently, novel methods …

Climate change is undermining the mental and physical health of global populations, but the
question of how it is affecting substance-use behaviors has not been systematically …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …

Given conceptual frameworks of addiction as a disease of intercommunicating brain
networks, examinations of network interactions may provide a holistic characterization of …

Background Substance use disorders (SUD) are a category of psychiatric disorders with a
large epidemiological and societal impact around the world. In the last decades, a large …

The prevention and treatment of substance use disorders (SUDs), including addiction, would
benefit from having better biomarkers for the classification of patients into categories that are …

Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …