Compromised MAPK signaling in human diseases: an update
EK Kim, EJ Choi - Archives of toxicology, 2015 - Springer
The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH 2-terminal
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …
ERK1/2 in immune signalling
Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …
[HTML][HTML] Survival of pancreatic cancer cells lacking KRAS function
MD Muzumdar, PY Chen, KJ Dorans, KM Chung… - Nature …, 2017 - nature.com
Activating mutations in the proto-oncogene KRAS are a hallmark of pancreatic ductal
adenocarcinoma (PDAC), an aggressive malignancy with few effective therapeutic options …
adenocarcinoma (PDAC), an aggressive malignancy with few effective therapeutic options …
[HTML][HTML] Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→ MEK→ ERK signaling and autophagy survival response
F Mollinedo, C Gajate - Annals of translational medicine, 2019 - ncbi.nlm.nih.gov
KRAS (Kirsten rat sarcoma viral oncogene homolog) is a major target in pancreatic ductal
adenocarcinoma (PDAC), but so far it has been perceived as “undruggable”, due to a lack of …
adenocarcinoma (PDAC), but so far it has been perceived as “undruggable”, due to a lack of …
Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras
J Akutagawa, TQ Huang, I Epstein, T Chang… - Leukemia, 2016 - nature.com
Chronic and juvenile myelomonocytic leukemias (CMML and JMML) are myelodysplastic/
myeloproliferative neoplasia (MDS/MPN) overlap syndromes that respond poorly to …
myeloproliferative neoplasia (MDS/MPN) overlap syndromes that respond poorly to …
[HTML][HTML] Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the βγ subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein …
Y Zhang, J Ying, D Jiang, Z Chang, H Li… - Journal of Biological …, 2015 - ASBMB
Recent studies have demonstrated that urotensin-II (U-II) plays important roles in
cardiovascular actions including cardiac positive inotropic effects and increasing cardiac …
cardiovascular actions including cardiac positive inotropic effects and increasing cardiac …
[HTML][HTML] Ras-related C3 botulinum toxin substrate (Rac) and Src family kinases (SFK) are proximal and essential for phosphatidylinositol 3-kinase (PI3K) activation in …
RF Xiang, D Stack, SM Huston, SS Li… - Journal of Biological …, 2016 - ASBMB
The activity of Rac in leukocytes is essential for immunity. However, its role in NK cell-
mediated anti-microbial signaling remains unclear. In this study, we investigated the role of …
mediated anti-microbial signaling remains unclear. In this study, we investigated the role of …
[HTML][HTML] Nesfatin-1 suppresses cardiac L-type Ca2+ channels through melanocortin type 4 receptor and the novel protein kinase C theta isoform pathway
J Ying, Y Zhang, S Gong, Z Chang, X Zhou… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Nesfatin-1 (NF-1), an anorexic nucleobindin-2 (NUCB2)-derived
hypothalamic peptide, acts as a peripheral cardiac modulator and it can induce negative …
hypothalamic peptide, acts as a peripheral cardiac modulator and it can induce negative …
[HTML][HTML] Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency
Z Sachs, RA Been, KJ DeCoursin, HT Nguyen… - …, 2016 - ncbi.nlm.nih.gov
Juvenile myelomonocytic leukemia is a rare myeloproliferative neoplasm characterized by
hyperactive RAS signaling. Neurofibromin1 (encoded by the NF1 gene) is a negative …
hyperactive RAS signaling. Neurofibromin1 (encoded by the NF1 gene) is a negative …
[HTML][HTML] Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1
RA Coover, TE Healy, L Guo, KE Chaney… - Acta Neuropathologica …, 2018 - Springer
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released
from the nerve in an activity dependent manner. We find that suppressing nerve activity in …
from the nerve in an activity dependent manner. We find that suppressing nerve activity in …