Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Ischemic stroke is the second cause of mortality and the first cause of long-term disability
constituting a serious socioeconomic burden worldwide. Approved treatments include …

Ischemic stroke (IS) caused by cerebral arterial occlusion is the leading cause of global
morbidity and mortality. Cellular oxidative stress and inflammation play a vital role in the …

Various age-related diseases involve systemic inflammation, ie a stereotyped series of acute
immune system responses, and aging itself is commonly associated with low-grade …

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with few
pharmacological treatments. Minocycline, a tetracycline derivative that inhibits microglial …

Stroke, including ischemic stroke and hemorrhagic stroke can cause massive neuronal
death and disruption of brain structure, which is followed by secondary inflammatory injury …

Inflammation plays a pivotal role in ischemia-induced retinal neovascularization. Targeting
microglia/macrophage-based neuroinflammation presents a promising therapeutic strategy …

Ischemic stroke, a primary cause of disability and the second leading cause of mortality, has
emerged as an urgent public health issue. Growing evidence suggests that the Cyclic GMP …

Ischemic stroke is a leading cause of mortality and morbidity worldwide, with
neuroinflammation playing a key role in its pathophysiology. Microglia, the primary immune …

Ischemic stroke (IS) has complex pathological mechanisms, and is extremely difficult to treat.
At present, the treatment of IS is mainly based on intravenous thrombolysis and mechanical …